زخم‌پوش‌های برپایه هیالورونیک اسید

نوع مقاله : مروری

نویسندگان

1 تهران، دانشگاه شهید بهشتی، دانشکده علوم شیمی و نفت، گروه پلیمر و شیمی مواد، کد پستی 1983969411

2 تهران، دانشگاه صنعتی شریف، دانشکده مهندسی شیمی و نفت، کد پستی 1458889694

3 تهران، پژوهشگاه رنگ، گروه پوشش‌های سطح و خوردگی، کد پستی 1668836471

4 تهران، پژوهشگاه رویان، پژوهشکده زیست‌شناسی و فناوری سلول‌های بنیادی جهاد دانشگاهی، مرکز تحقیقات علوم سلولی، گروه مهندسی سلول، صندوق پستی 148-16635

5 تهران، دانشگاه الزهرا، دانشکده میکروبیولوژی، کد پستی 1993893973

6 تهران، دانشگاه صنعتی خواجه نصیر طوسی، دانشکده شیمی، کد پستی 1541849611

7 تهران، دانشگاه شهید بهشتی، دانشکده علوم و فناوری زیستی، گروه علوم جانوری و زیست‌شناسی دریا، کد پستی 198396411

8 تهران، دانشگاه علامه طباطبایى، دانشکده مدیریت و حسابدارى، کد پستی 1489684511

9 تهران، دانشگاه صنعتی امیرکبیر، دانشکده مهندسی نساجی، کد پستی 1591634311

10 تهران، پژوهشگاه رویان، پژوهشکده زیست‌شناسی و فناوری سلول‌های بنیادی جهاد دانشگاهی، مرکز تحقیقات علوم سلولی، گروه مهندسی سلول، کد پستی 1651153511

چکیده

رشد روزافزون جمعیت جهان و افزایش بیماری‌های زمینه‌ای همچون دیابت، موجب روند فزاینده‌ آسیب‌های پوستی و تحمیل هزینه‌های گزاف بر نظام سلامت شده است. پیچیدگی و فرایند چندمرحله‌ای ترمیم زخم، اهمیت معرفی محصولات کارآمد به‌منظور ارائه‌ درمان مؤثر آسیب‌های پوستی را نمایان می‌سازد. از این رو، معرفی محصولات نوین ترمیم زخم برای درمان مؤثر این نوع آسیب‌ها ضروری است. استفاده از زخم‌پوش‌های نوین در سال‌های اخیر مورد توجه قرار گرفته است. این زخم‌پوش‌ها با فراهم‌آوردن شرایط فیزیکی و زیستی مناسب، بازسازی پوست را آسان می‌کنند. زخم‌پوش‌ها با اشکال اسفنجی، لیفی، هیدروژلی، فیلمی و پودری برای درمان زخم‌های مختلف تولید می‌شوند. زیست‌مواد طبیعی و سنتزی گوناگون برای ساخت این محصولات استفاده شده‌اند که از میان آن‌ها، هیالورونیک اسید (HA) به‌دلیل ویژگی‌های مطلوب زیستی از اهمیت ویژه‌ای برخوردار است. این ماده به‌عنوان یکی از اجزای اصلی تشکیل‌دهنده ماتریس برون‌یاخته‌ای پوست، به طور مستقیم در مراحل چهارگانه‌ ترمیم زخم اثرگذار است. این ویژگی‌های زیستی به همراه آب‌دوستی زیاد موجب توجه ویژه به این ماده به‌عنوان گزینه‌ای امیدبخش در ترمیم آسیب‌های پوستی شده است. در این مقاله، پس از بیان ساختار پوست و انواع زخم‌ها، فرایند ترمیم زخم توضیح داده می‌شود. سپس، زخم‌پوش‌های سنتی و تجاری و انواع آن‌ها معرفی می‌شوند. در ادامه، پس از معرفی رایج‌ترین زیست‌مواد استفاده‌شده برای ساخت زخم‌پوش‌ها، ساختار هیالورونیک اسید، سازوکار تخریب و نیز نقش این ماده در مراحل مختلف ترمیم زخم به‌تفصیل شرح داده می‌شوند. همچنین انواع زخم‌پوش‌های بر پایه هیالورونیک اسید معرفی می‌شوند. در نهایت، انواع زخم‌پوش‌های تجاری بر پایه این پلیمر معرفی شده و مروری بر بازار جهانی زخم‌پوش‌ها برای ترسیم چشم‌انداز مصرف این محصولات ارائه می‌شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Hyaluronic Acid-Based Wound Dressings

نویسندگان [English]

  • Sarvenaz Pakian 1
  • Maryam Alizadeh 2
  • Alireza Mouraki 3
  • Maryam Tavakolizadeh 4
  • Kimia Samadi 5
  • Maryam Radpour 6
  • Ali Amirian 7
  • Ailin Javidi 8
  • Zahra Mohammadi Ghermezgoli 9
  • Hamed Daemi 10
1 Department of Polymer and Materials Chemistry, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, Postal Code: 1983969411, Tehran, Iran
2 Department of Chemical & Petroleum Engineering, Sharif University of Technology, Postal Code: 1458889694, Tehran, Iran
3 Department of Surface Coatings and Corrosion, Institute for Color Science and Technology, Postal Code: 1668836471, Tehran, Iran
4 Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, P.O. Box: 16635- 148, Tehran, Iran
5 Department of Microbiology, Alzahra University, Postal Code: 1993893973, Tehran, Iran
6 Faculty of Chemistry, Khajeh Nasir Toosi University of Technology, Postal Code: 1541849611, Tehran, Iran
7 Department of Animal Sciences and Marine Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Postal Code: 198396411, Tehran, Iran
8 Department of Technology and Entrepreneurship Management, Allameh Tabataba'i University, Postal Code: 1489684511 , Tehran, Iran
9 Department of Textile Engineering, Amirkabir University of Technology, Postal Code: 1591634311, Tehran, Iran
10 Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, P.O. Box: 16635- 148, Tehran, Iran
چکیده [English]

The growing world's population and the increase of underlying diseases such as diabetes have caused an increasing trend of skin damage and imposed high costs on the healthcare system. The complex and multi-step nature of wound healing highlights the importance of introducing efficient products for effective treatment of skin injuries. Therefore, it is necessary to introduce new wound healing products to treat these types of injuries effectively. The modern wound dressings have received much attention in recent years. These dressings facilitate skin regeneration by providing suitable physical and biological conditions. Wound dressings are produced in sponge, fibrous, hydrogel, film, and powder forms to treat different wounds. Various natural and synthetic biomaterials have been used to make these products, among which hyaluronic acid (HA) is particularly important due to its unique biological properties. As one of the main constituents of the skin's extracellular matrix, this substance is directly effective in the four stages of wound healing. These biological characteristics and high hydrophilicity have attracted special attention to this material as a promising option for repairing skin damage. In this article, the wound healing process is explained after describing the skin structure and types of wounds. Then, traditional and commercial dressings and their types are introduced. In the following, by introducing the most common biological materials used to make wound dressings, the structure of HA, the mechanism of degradation, and the role of this material in different stages of wound healing are described in detail. Also different types of HA-based wound dressings in the literature are discussed. Finally some types of commercial wound dressings based on this polymer are introduced and an overview of the global market for wound dressings is provided to outline the perspective of the consumption of these products.

کلیدواژه‌ها [English]

  • Wound dressing
  • Hyaluronic acid
  • Skin
  • Wound healing
  • Wound

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مجله علوم و تکنولوژی پلیمر
دوره 37، شماره 1 - شماره پیاپی 189
فروردین و اردیبهشت 1403
صفحه 27-46

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